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ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease
Yohei Shibuya1, Catherine Cy Chang1, Ta-Yuan Chang1
1Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA.
Abstract:
Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.
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