Related Experiment Video
Updated: Mar 28, 2026

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread
Published on: August 16, 2013
Piracy on the molecular level: human herpesviruses manipulate cellular chemotaxis
Caleb Cornaby1, Anne Tanner1, Eric W Stutz1
1Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
Abstract:
Cellular chemotaxis is important to tissue homeostasis and proper development. Human herpesvirus species influence cellular chemotaxis by regulating cellular chemokines and chemokine receptors. Herpesviruses also express various viral chemokines and chemokine receptors during infection. These changes to chemokine concentrations and receptor availability assist in the pathogenesis of herpesviruses and contribute to a variety of diseases and malignancies. By interfering with the positioning of host cells during herpesvirus infection, viral spread is assisted, latency can be established and the immune system is prevented from eradicating viral infection.
Related Concept Videos
Chemotaxis and Direction of Cell Migration
Intracellular Movement of Viruses and Bacteria
Chemotaxis in E. coli
Cell Migration
Cell Polarization by Rho Proteins
Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....

