Related Experiment Video

Updated: Mar 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study

Hao Xue1, Jianli Wang2, Jinhong Hou2

  • 1Department of Cardiology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, People's Republic of China.

Plos One
|December 17, 2015
PubMed

Insights

Prehypertension significantly increases the risk of developing chronic kidney disease (CKD) in the Chinese population. This study found prehypertension is an independent risk factor for new CKD events.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Hypertension is a known cause of chronic kidney disease (CKD).
  • The association between prehypertension and CKD risk remains controversial.
  • Understanding prehypertension's role in CKD is crucial for public health.

Purpose of the Study:

  • To investigate if prehypertension elevates the risk of CKD events in the Chinese population.
  • To quantify the association between prehypertension and incident CKD.

Main Methods:

  • Prospective study involving 20,034 individuals with prehypertension and 12,351 with ideal blood pressure.
  • CKD defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m².
  • Kaplan-Meier and multivariate Cox regression analyses were employed.

Main Results:

  • Higher cumulative incidence of CKD events in the prehypertensive group (2.10%) compared to the ideal blood pressure group (1.46%).
  • Prehypertension was associated with a 1.69-fold increased risk of new CKD events.
  • Increased risks observed in both females (1.68-fold) and males (2.14-fold) after adjusting for risk factors.

Conclusions:

  • Prehypertension is identified as an independent risk factor for new-onset CKD in the Chinese population.
  • These findings highlight the importance of managing prehypertension to prevent kidney disease progression.
  • Early intervention for prehypertension may mitigate CKD incidence.

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.1K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
620
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
945
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.8K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
714