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Association Areas of the Cortex

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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

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Frontotemporal Dysfunction in Amyotrophic Lateral Sclerosis: A Discriminant Function Analysis.

Andreas Nidos¹, Dimitrios S Kasselimis, Panagiotis G Simos

¹First Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Neuro-Degenerative Diseases

|December 17, 2015

Summary

This summary is machine-generated.

A brief neuropsychological battery effectively identifies extramotor dysfunction (EMd) in amyotrophic lateral sclerosis (ALS) patients, showing high sensitivity and specificity. This tool aids in diagnosing cognitive and behavioral deficits when comprehensive testing is limited.

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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

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Published on: October 13, 2016

Area of Science:

Neuroscience
Neurology
Psychology

Background:

Extramotor dysfunction (EMd) affects up to 52% of amyotrophic lateral sclerosis (ALS) patients.
Assessing EMd is crucial for comprehensive patient care in ALS.

Purpose of the Study:

To evaluate the clinical utility of a brief neuropsychological battery for detecting cognitive, behavioral, and language deficits in ALS.
To establish the effectiveness of a concise assessment for EMd in ALS.

Main Methods:

A cohort of 34 ALS patients (aged 44-89) underwent testing with a brief neuropsychological battery.
Patients were initially classified as EMd or non-EMd using the Frontal Assessment Battery (FAB).
Discriminant analysis was employed to analyze the neuropsychological data.

Main Results:

Significant differences (p < 0.01) were observed across all measures between EMd and non-EMd groups.
Discriminant analysis identified a single canonical function that accurately classified EMd patients.
The proposed battery demonstrated 88.2% sensitivity and specificity compared to the FAB.

Conclusions:

The brief neuropsychological battery is a valuable clinical tool for assessing EMd in ALS, particularly when resources for extensive testing are scarce.
Discriminant function analysis is highlighted as an important method in clinical neuropsychological assessment.
The study discusses the psychometric validity of using neuropsychological tests for ALS-frontotemporal dementia diagnosis.