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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Methods of reducing fever01:22

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Homeostatic Imbalances in Body Temperature01:19

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Increased Body Temperature01:25

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Thermal Stress01:09

Thermal Stress

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If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...
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Updated: Mar 28, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

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Acid-base optimization during hypothermia.

Leah Bergman1, Justin B Lundbye1

  • 1University of Connecticut School of Medicine, The Hospital of Central Connecticut, 100 Grand Street, New Britain, CT 06050, USA.

Best Practice & Research. Clinical Anaesthesiology
|December 17, 2015
PubMed
Summary
This summary is machine-generated.

Therapeutic hypothermia (TH) improves outcomes for cardiac arrest (CA) survivors by reducing injury. Careful monitoring and management of acidosis after return of spontaneous circulation (ROSC) are crucial for optimal patient recovery.

Keywords:
acidosisalpha-statcardiac arrestlactic acidpH-stattherapeutic hypothermia

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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Biochemistry

Background:

  • Cardiac arrest (CA) leads to significant hemodynamic and metabolic issues, impacting patient prognosis.
  • Therapeutic hypothermia (TH) is a standard treatment for CA survivors, improving neurological outcomes by mitigating reperfusion injury and acid-base disturbances.
  • Mild acidosis during TH is often tolerated, but significant acidosis post-ROSC requires careful management.

Purpose of the Study:

  • To highlight the importance of monitoring and managing acidosis following return of spontaneous circulation (ROSC) in cardiac arrest survivors.
  • To discuss the appropriate use of bicarbonate in severe acidosis during post-cardiac arrest care.
  • To emphasize the temperature dependency of blood gas analysis and the need for potential corrections.

Main Methods:

  • Review of current therapeutic hypothermia protocols and their impact on acid-base balance.
  • Analysis of management strategies for acidosis in post-cardiac arrest patients.
  • Discussion of blood gas sample handling and interpretation, considering temperature effects.

Main Results:

  • Therapeutic hypothermia (TH) offers neuroprotective benefits despite potential mild acidosis.
  • Severe acidosis post-ROSC necessitates vigilant monitoring and specific management, such as continuous bicarbonate infusion.
  • Blood gas values are temperature-dependent, requiring calculated corrections for accurate interpretation.

Conclusions:

  • Effective management of acidosis is critical for improving outcomes in cardiac arrest survivors undergoing therapeutic hypothermia.
  • Judicious use of bicarbonate and accurate interpretation of temperature-corrected blood gas values are essential components of post-ROSC care.
  • Optimizing acid-base management alongside TH can further enhance neurological recovery in cardiac arrest survivors.