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Updated: Mar 28, 2026
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Cortical event-related potentials in Alzheimer's disease and frontotemporal lobar degeneration
Lei Chen1, Yuying Zhou2, Li Liu3
1Department of Neurology, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China.
Background:
The aim of the present study was to evaluate changes in event-related evoked potentials (ERPs) in patients with Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD).
Methods:
A total of 42AD patients, 29 behavioral variant frontotemporal dementia (bvFTD) patients, and 30 healthy controls were examined. The subjects underwent neuropsychological tests and cognitive (N200 and P300) ERP examination. The amplitudes and latencies of the cortical potentials were compared among AD and bvFTD patients and control subjects.
Results:
No differences in the ERP latencies and amplitudes for the N200 component were observed among the groups. AD patients exhibited significantly longer latencies of P300 at both Pz (p=0.002) and Cz (p=0.007) compared with the controls. Patients with bvFTD displayed longer P300 latencies at Pz (p=0.046) and a smaller amplitude at both Pz (p=0.000) and Cz (p=0.23) than the controls.
Conclusions:
The results of the present study confirm the relevance of ERPs in evaluating cognitive disorders. These non-invasive examinations have the potential to contribute to the diagnosis of AD and bvFTD.
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