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Diabetes mellitus and white matter hyperintensity.
Yoshiaki Tamura1, Atsushi Araki1
1Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Geriatrics & Gerontology International
|December 17, 2015
Summary
White matter hyperintensity (WMH) is linked to cognitive decline. In elderly patients with diabetes, factors accelerating WMH progression require further study, with insulin resistance as a potential exacerbating factor.
Area of Science:
- Neurology
- Geriatrics
- Vascular Medicine
Background:
- White matter hyperintensity (WMH) on MRI indicates small vessel damage.
- WMH is associated with stroke, cognitive decline, and geriatric syndromes.
- Diabetes mellitus is increasingly recognized as a risk factor for WMH progression.
Purpose of the Study:
- To explore factors accelerating WMH formation in elderly patients with diabetes.
- To clarify the role of insulin resistance, hypertension, and dyslipidemia in WMH progression.
Main Methods:
- Review of existing literature on WMH and diabetes.
- Analysis of correlations between WMH severity and cognitive decline in diabetic patients.
Main Results:
- WMH severity correlates with cognitive decline in diabetic patients.
- Insulin resistance is a suspected exacerbating factor for WMH.
- The precise impact of hypertension, dyslipidemia, and other vascular risk factors remains unclear.
Conclusions:
- WMH is a significant marker for cognitive decline in diabetic elderly.
- Further research is needed to define factors accelerating WMH in this population.
- Understanding these factors is crucial for managing geriatric syndromes in diabetic patients.
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