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Diabetes mellitus and white matter hyperintensity

Yoshiaki Tamura1, Atsushi Araki1

  • 1Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

Geriatrics & Gerontology International
|December 17, 2015
PubMed

Insights

White matter hyperintensity (WMH) is linked to cognitive decline. In elderly patients with diabetes, factors accelerating WMH progression require further study, with insulin resistance as a potential exacerbating factor.

Area of Science:

  • Neurology
  • Geriatrics
  • Vascular Medicine

Background:

  • White matter hyperintensity (WMH) on MRI indicates small vessel damage.
  • WMH is associated with stroke, cognitive decline, and geriatric syndromes.
  • Diabetes mellitus is increasingly recognized as a risk factor for WMH progression.

Purpose of the Study:

  • To explore factors accelerating WMH formation in elderly patients with diabetes.
  • To clarify the role of insulin resistance, hypertension, and dyslipidemia in WMH progression.

Main Methods:

  • Review of existing literature on WMH and diabetes.
  • Analysis of correlations between WMH severity and cognitive decline in diabetic patients.

Main Results:

  • WMH severity correlates with cognitive decline in diabetic patients.
  • Insulin resistance is a suspected exacerbating factor for WMH.
  • The precise impact of hypertension, dyslipidemia, and other vascular risk factors remains unclear.

Conclusions:

  • WMH is a significant marker for cognitive decline in diabetic elderly.
  • Further research is needed to define factors accelerating WMH in this population.
  • Understanding these factors is crucial for managing geriatric syndromes in diabetic patients.
Keywords:
deep white matter hyperintensitydiabetes mellitusgeriatric syndromeparaventricular leukoaraiosiswhite matter hyperintensity

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