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[Hepatic veno-occlusive disease: indication for liver transplantation?]
M Decurtins1, M Turina, F Largiadèr
1Departement Chirurgie, Universitätsspital Zürich.
Insights
Liver transplantation is a successful treatment for Budd-Chiari syndrome. It is considered for severe cases involving liver vein thrombosis (veno-occlusive disease) when other methods are not suitable.
Area of Science:
- Hepatology
- Transplantation Surgery
- Vascular Surgery
Background:
- Budd-Chiari syndrome is a rare condition characterized by hepatic venous outflow obstruction.
- Liver replacement (transplantation) has been a successful management strategy since 1976.
- Transcaval resection with hepato-atrial anastomosis offers a less invasive approach for Budd-Chiari syndrome.
Observation:
- This report focuses on liver transplantation as a treatment option.
- Liver transplantation is reserved for specific complex cases.
- Central liver vein thrombosis, also known as veno-occlusive disease, presents a critical challenge.
Findings:
- Liver transplantation can be a highly effective intervention.
- It is particularly beneficial in desperate situations with central liver vein thrombosis.
- The procedure offers a viable solution for refractory Budd-Chiari syndrome.
Implications:
- Liver transplantation remains a crucial option for severe Budd-Chiari syndrome.
- This approach expands treatment possibilities for patients with limited options.
- Further research into optimizing liver transplantation for veno-occlusive disease is warranted.
Abstract:
Since 1976 liver replacement has become a widespread and successful procedure in the management of acute or chronic Budd-Chiari syndrome. Since transcaval resection of the liver with direct hepato-atrial anastomosis provides a less formidable method of treating Budd-Chiari syndrome, we consider liver transplantation only in cases with thrombosis of central liver veins (veno-occlusive disease). Even in such a desperate situation liver transplantation can be very helpful, as documented in this report.