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Decoding the stem cell quiescence cycle--lessons from yeast for regenerative biology
Jyotsna Dhawan1, Sunil Laxman2
1Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India CSIR Center for Cellular and Molecular Biology, Hyderabad, India jdhawan@instem.res.in sunil@instem.res.in.
Journal of Cell Science
|December 17, 2015
Summary
Yeast studies offer crucial insights into mammalian stem cell quiescence, a state vital for regenerative medicine. Understanding yeast cell cycle regulation advances our knowledge of stem cell behavior and therapies.
Area of Science:
- Cell Biology
- Regenerative Medicine
- Yeast Genetics
Background:
- Mammalian stem cell biology has advanced, yet translation to regenerative medicine faces challenges.
- Saccharomyces cerevisiae (yeast) research provides foundational concepts for stem cell behavior.
- Quiescent adult mammalian stem cells are critical for tissue repair and regeneration.
Purpose of the Study:
- To examine how yeast biology research informs our understanding of mammalian stem cell quiescence.
- To highlight conserved mechanisms controlling entry and exit from quiescence.
- To underscore the potential of yeast studies for advancing regenerative medicine.
Main Methods:
- Comparative analysis of Saccharomyces cerevisiae and mammalian stem cell literature.
- Review of metabolic, signaling, and gene regulatory events in yeast quiescence.
- Examination of conserved pathways between yeast and mammalian systems.
Main Results:
- Yeast studies have contributed significantly to the conceptual framework of stem cell behavior.
- Metabolic, signaling, and gene regulatory events in yeast quiescence show parallels with mammalian systems.
- Quiescence is a regulated program extending beyond mere cell division cessation.
Conclusions:
- Insights from yeast biology are fundamental to understanding mammalian stem cell quiescence.
- Conserved mechanisms in yeast offer a model for studying stem cell regulation.
- Continued yeast research promises to accelerate progress in regenerative medicine.
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