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Published on: January 27, 2023
Insights
Patent ductus arteriosus (PDA) in preterm infants remains controversial despite decades of research. This report reviews evidence to guide the evaluation and treatment of prolonged ductal patency in newborns.
Area of Science:
- Neonatal Medicine
- Pediatric Cardiology
- Perinatal Research
Background:
- Patent ductus arteriosus (PDA) is common in preterm infants.
- Significant uncertainty and controversy persist regarding PDA's significance, evaluation, and management.
- Clinical practice for PDA in preterm infants shows substantial heterogeneity.
Purpose of the Study:
- To summarize current evidence on the evaluation and treatment of PDA in preterm infants.
- To address the controversy surrounding prolonged ductal patency in the neonatal period.
- To guide clinical practice for managing PDA in vulnerable preterm populations.
Main Methods:
- Systematic review of existing literature on PDA in preterm infants.
- Analysis of clinical research and experience spanning nearly six decades.
- Evidence synthesis to inform clinical decision-making.
Main Results:
- Inconclusive findings due to persistent controversy and heterogeneity in practice.
- Identification of knowledge gaps in PDA evaluation and management.
- Need for standardized approaches to prolonged ductal patency.
Conclusions:
- Further research is needed to resolve controversies surrounding PDA in preterm infants.
- Standardized guidelines are essential to reduce clinical practice heterogeneity.
- Evidence-based evaluation and treatment strategies are crucial for optimal infant outcomes.
Abstract:
Despite a large body of basic science and clinical research and clinical experience with thousands of infants over nearly 6 decades,(1) there is still uncertainty and controversy about the significance, evaluation, and management of patent ductus arteriosus in preterm infants, resulting in substantial heterogeneity in clinical practice. The purpose of this clinical report is to summarize the evidence available to guide evaluation and treatment of preterm infants with prolonged ductal patency in the first few weeks after birth.
