Related Experiment Video

Updated: Mar 28, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

The predictive role of circulating microparticles in patients with chronic heart failure

Alexander E Berezin1, Alexander A Kremzer2, Yulia V Martovitskaya3

  • 1Internal Medicine Department, State Medical University, 26, Mayakovsky Av., Zaporozhye UA-69035, Ukraine.

BBA Clinical
|December 18, 2015
PubMed

Insights

Circulating microparticles with an apoptotic phenotype may help predict cardiovascular events in patients with chronic heart failure (CHF). These markers, alongside NT-pro-BNP and hs-CRP, improve risk assessment for fatal and non-fatal outcomes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Chronic heart failure (CHF) poses a significant risk for cardiovascular events.
  • Accurate risk assessment is crucial for managing CHF patients.
  • Identifying novel biomarkers for cardiovascular event prediction in CHF is an ongoing research area.

Purpose of the Study:

  • To evaluate the utility of circulating microparticles with apoptotic and non-apoptotic phenotypes in assessing the 3-year risk of fatal and non-fatal cardiovascular events in CHF patients.
  • To determine if these microparticles improve upon existing risk prediction models.

Main Methods:

  • Prospective cohort study of 388 CHF patients over 3 years.
  • Measurement of NT-pro brain natriuretic peptide (NT-pro-BNP), high-sensitivity C-reactive protein (hs-CRP), and endothelial apoptotic microparticles (EMPs) at baseline.
  • Analysis of cardiovascular events, including fatal outcomes, hospitalizations, and cumulative endpoints using logistic regression.

Main Results:

  • Elevated levels of specific EMPs (CD144+/CD31+/annexin V+ and CD31+/annexin V+) were significantly associated with cumulative cardiovascular endpoints in multivariate analysis.
  • These EMPs, when added to the standard ABC model, improved the relative integrated discrimination index (IDI) by 11.4% and 10.5%, respectively.
  • Factors like NYHA class, reduced left ventricular ejection fraction (LVEF), NT-pro-BNP, and hs-CRP were also significant predictors.

Conclusions:

  • The apoptotic phenotype of circulating microparticles is associated with 3-year combined clinical outcomes in CHF patients.
  • Apoptotic EMPs show potential as valuable biomarkers for cardiovascular risk stratification in CHF.
  • These findings suggest that EMPs can enhance existing risk assessment models for CHF patients.
Abstract

Keywords:
Cardiovascular outcomesChronic heart failureMicroparticlesPredictive value

More Related Videos

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells09:26

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

9.6K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.8K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
742
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.5K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.0K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
751
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K