Systemic sarcoidosis mimicking malignant metastatic disease

Area of Science:

• Internal Medicine
• Pathology
• Radiology

Background:

• Sarcoidosis is an inflammatory disease characterized by granuloma formation in various organs.
• Systemic sarcoidosis can present with diverse clinical manifestations, often posing diagnostic challenges.

Observation:

• A patient presented with symptoms suggestive of malignant metastatic disease.
• Imaging and pathological examinations revealed widespread sarcoidosis affecting the liver, pancreas, lungs, lymph nodes, and bones.

Findings:

• The diagnostic workup successfully ruled out malignancy.
• Histopathological confirmation of non-caseating granulomas established the diagnosis of sarcoidosis.

Implications:

• This case highlights the importance of considering sarcoidosis in the differential diagnosis of unexplained multi-organ system involvement.
• Prompt diagnosis and initiation of systemic corticosteroid therapy resulted in significant clinical improvement.