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Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
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Airway resistance and reactance are affected in systemic sclerosis
David Aronsson1, Roger Hesselstrand2, Gracijela Bozovic3
1Respiratory Medicine and Allergology, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden.
European Clinical Respiratory Journal
|December 18, 2015
Summary
Impulse oscillometry (IOS) can assess lung impairment in systemic sclerosis (SSc). IOS parameters correlate with lung fibrosis, offering a potential tool for evaluating SSc-related interstitial lung disease.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Diagnostic Imaging
Background:
- Interstitial lung disease is a common early complication of systemic sclerosis (SSc).
- Evaluating lung impairment in SSc patients is crucial for timely intervention.
- Impulse oscillometry (IOS) is a non-invasive technique for assessing lung function.
Purpose of the Study:
- To investigate the utility of impulse oscillometry (IOS) in evaluating lung impairment in patients with systemic sclerosis (SSc).
- To determine the correlation between IOS parameters and fibrotic changes in the lungs of SSc patients.
Main Methods:
- Seventy-eight SSc patients (65 limited cutaneous SSc, 13 diffuse cutaneous SSc) and 26 healthy controls underwent high-resolution computed tomography (HRCT) and pulmonary function tests, including spirometry, IOS, and single breath CO diffusion capacity.
- IOS parameters measured included peripheral airway resistance (R5-R20), reactance area, and resonant frequency.
Main Results:
- Patients with limited cutaneous SSc exhibited higher peripheral airway resistance (R5-R20) and reactance area compared to diffuse cutaneous SSc and healthy controls.
- Airway reactance demonstrated a correlation with fibrotic findings on HRCT, such as ground glass opacities and reticulations.
- Specific IOS values differed significantly between SSc subtypes and controls, indicating distinct patterns of lung involvement.
Conclusions:
- Impulse oscillometry parameters are associated with lung fibrosis in patients with systemic sclerosis.
- IOS shows potential as a valuable tool for assessing lung involvement and fibrosis in SSc.
- Further research can explore IOS for monitoring disease progression and treatment response in SSc-related lung disease.
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