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Multifactorial determinants of cognition - Thyroid function is not the only one.

Roy Moncayo1, Karina Ortner1

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Thyroid function is not the main driver of cognitive development. Magnesium deficiency is linked to both thyroid issues and cognitive deficits, suggesting supplementation may help.

Keywords:
CognitionHippocampusMagnesiumNMDA receptorsPrenatal maternal stressThyroid function

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Cognitive Science

Background:

  • Historically, hypothyroidism and iodine deficiency were linked to cognitive development.
  • Current research questions this link due to iodine supplementation and improved hypothyroidism treatments.
  • Neuroscience offers new insights into cognition beyond thyroid function.

Purpose of the Study:

  • To review publications on thyroid function and cognition.
  • To explore the relationship between stress and cognitive function.
  • To investigate the role of magnesium in thyroid function and cognition.

Main Methods:

  • Literature review of original and current publications.
  • Analysis of determinants of intelligence and cognition.
  • Examination of the impact of physical, psychological, and prenatal stress.

Main Results:

  • Recent studies show no significant impact of maternal thyroid medication on fetal intellectual development.
  • Neuroscience provides a more comprehensive explanation for cognitive processes.
  • Stress, particularly prenatal stress, is identified as a significant factor influencing cognition.

Conclusions:

  • Cognition is multifactorial, influenced by nutrition, infection, and stress, not solely thyroid function.
  • Magnesium deficiency is implicated as a fundamental mechanism affecting both thyroid function and cognitive abilities.
  • Magnesium supplementation may improve latent hypothyroidism and mild cognitive deficits.