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A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
Postexercise Hypotension after Heart Transplant: Water- versus Land-Based Exercise
Rafael Ertner Castro1, Guilherme Veiga Guimarães, José Messias Rodrigues Da Silva
11Exercise and Chronic Disease Research Laboratory, Physical Education Department, School of Sciences, São Paulo State University-UNESP, Bauru, BRAZIL; 2Heart Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BRAZIL.
Both heated water-based exercise and land-based exercise significantly reduced blood pressure in heart transplant recipients. These findings suggest exercise is a valuable tool for managing hypertension in this population.
Area of Science:
- Cardiology
- Exercise Physiology
- Nephrology
Background:
- Heart transplant recipients (HTx) exhibit a high incidence of hypertension.
- Exercise training is known to reduce blood pressure (BP) in HTx.
- The acute effects of a single exercise bout on BP in HTx are not well understood.
Purpose of the Study:
- To investigate the acute effects of heated water-based exercise (HEx) compared to land-based exercise (LEx) on ambulatory blood pressure (ABP) in HTx.
- To compare the BP-lowering effects of HEx and LEx in heart transplant recipients.
Main Methods:
- Eighteen clinically stable HTx underwent 30-minute sessions of HEx, LEx, and a non-exercise control (CON) in a randomized order.
- Exercise intensity was standardized using the Rating of Perceived Exertion (RPE) scale (11-13).
- Twenty-four-hour ambulatory blood pressure monitoring was conducted after each intervention.
Main Results:
- Daytime diastolic BP was significantly lower after HEx compared to CON.
- Daytime diastolic BP showed a trend towards reduction after LEx compared to CON.
- Both HEx and LEx demonstrated significant hourly reductions in systolic and diastolic BP compared to CON, with no significant differences between HEx and LEx.
Conclusions:
- Both heated water-based exercise and land-based exercise induce similar acute reductions in ambulatory blood pressure in heart transplant recipients.
- These exercise modalities may serve as effective tools for managing hypertension in the high-risk HTx population.
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