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Updated: Mar 28, 2026
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Current Perspective on the Pathogenesis of Small Intestinal Neuroendocrine Tumors: Progress in Biomarkers and
Ying-Xuan Chen1, Jing-Yuan Fang1
1Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China.
Background:
Neuroendocrine tumors of the gastrointestinal tract differ in their histopathologic and clinical presentation. Small intestinal neuroendocrine tumors (SI-NETs), representing only a small portion within gastrointestinal malignancies, are often associated with a delayed diagnosis due to their non-specific symptoms. The increased incidence of SI-NETs during the last decades demands earlier diagnosis and more effective treatment, which both rely on a better understanding on the underlying molecular mechanisms.
Summary:
The purpose of this review is to discuss the biomolecular changes responsible for the pathogenesis of SI-NETs, and potential biomarkers in the diagnostic and prognostic evaluation.
Insights
Small intestinal neuroendocrine tumors (SI-NETs) present with vague symptoms, leading to delayed diagnosis. Understanding their molecular changes is key for earlier detection and improved treatment of these rare gastrointestinal cancers.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Biology
Background:
- Neuroendocrine tumors of the gastrointestinal tract exhibit diverse histopathology and clinical features.
- Small intestinal neuroendocrine tumors (SI-NETs) are rare gastrointestinal malignancies often diagnosed late due to nonspecific symptoms.
- Rising incidence of SI-NETs necessitates earlier diagnosis and effective therapies, driven by molecular insights.
Purpose of the Study:
- To review the biomolecular alterations driving small intestinal neuroendocrine tumor (SI-NET) pathogenesis.
- To identify potential biomarkers for the diagnostic and prognostic assessment of SI-NETs.
Main Methods:
- Literature review of studies on SI-NET pathogenesis.
- Analysis of molecular mechanisms and biomarker research in SI-NETs.
Main Results:
- Specific biomolecular changes contribute to SI-NET development.
- Identified potential biomarkers for improved diagnostic and prognostic evaluation.
Conclusions:
- Understanding SI-NET molecular pathogenesis is crucial for clinical advancement.
- Biomarkers hold promise for enhancing the diagnosis and prognosis of SI-NETs.
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