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Exhaled nitric oxide in school children: Searching for the lost variability
P W Garcia-Marcos1, M J Soriano-Pérez2, V Perez-Fernández1
1Department of General Pediatrics, Arrixaca University Children's Hospital, University of Murcia, Murcia, Spain.
Allergologia Et Immunopathologia
|December 18, 2015
Summary
Factors like asthma and rhinoconjunctivitis explain little of the variability in fractional exhaled nitric oxide (FeNO) levels in children. This low explanatory power may affect FeNO
Area of Science:
- Pediatric respiratory health
- Allergy and immunology
- Biomarker research
Background:
- Fractional exhaled nitric oxide (FeNO) is a marker of airway inflammation.
- Understanding factors influencing FeNO variability is crucial for its clinical application.
- Asthma and rhinoconjunctivitis are common childhood conditions associated with inflammation.
Purpose of the Study:
- To investigate factors influencing FeNO levels in school children.
- To determine the extent to which individual, family, and environmental factors explain FeNO variability.
- To assess the impact of asthma and rhinoconjunctivitis on FeNO values.
Main Methods:
- FeNO was measured in 240 children aged 6-12 years using a Niox-Mino™ device.
- Validated questionnaires assessed symptoms and environmental exposures.
- Clinical records confirmed diagnoses; height and weight were measured.
- Multivariate regression and stepwise analysis identified key influencing variables.
Main Results:
- FeNO levels were higher in children with rhinoconjunctivitis, asthma, or both compared to controls.
- Predictive models explained only 20-27% of the inter-individual variability in FeNO.
- Asthma and rhinoconjunctivitis were significant, but not the sole, determinants of FeNO.
Conclusions:
- Individual, family, and environmental factors explain a small proportion of FeNO variability in children.
- The limited explanatory power suggests FeNO's diagnostic utility for asthma may be constrained.
- Further research is needed to identify additional factors influencing FeNO.
