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Published on: September 1, 2010
Sonic Hedgehog Signalling Pathway and Ameloblastoma - A Review
Pallavi Mishra1, Abikshyeet Panda2, Alokenath Bandyopadhyay3
1Postgraduate Trainee, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental sciences, KIIT , Bhubaneswar, Odisha, India .
Abstract:
Ameloblastoma is a benign but aggressive odontogenic neoplasm arising from odontogenic epithelium. Many theories have been proposed to explain the pathogenesis of ameloblatoma. Numerous signalling pathways have been implicated to be associated in the development and progression of this neoplasm. Studies have found association of various signalling molecules of Sonic Hedgehog Pathway, namely SHH, PTCH1, SMO, Gli 1, Gli 2, Gli 3, with ameloblastoma. Knowledge about this pathway will help us to understand the nature and behaviour of this neoplasm. This will open the door towards new treatment modalities.
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