[Association between serum leptin, adiponectin, visfatin, obesity and hypertension in female]
Kun Xia, Rongjing Ding, Yuan Yang1
1Cardiology Center of Peking University People's Hospital, Beijing 100044, China;
Insights
Adiponectin and visfatin levels are linked to obesity and high blood pressure in women. Lower adiponectin and higher visfatin may increase hypertension risk, suggesting their role in female obesity-related hypertension.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Metabolic Syndrome
Background:
- Obesity and hypertension are significant global health concerns, particularly in women.
- Adipokines, such as leptin, adiponectin, and visfatin, are signaling molecules produced by adipose tissue that influence metabolic and cardiovascular health.
- The interplay between these adipokines, obesity, and hypertension requires further elucidation.
Purpose of the Study:
- To investigate the association between serum levels of leptin, adiponectin, and visfatin with obesity and essential hypertension in a cohort of female subjects.
- To determine the predictive value of these adipokines in relation to body mass index (BMI), blood pressure, and waist circumference.
Main Methods:
- A cross-sectional study involving 206 female participants categorized into four groups based on BMI and blood pressure: obesity with hypertension, non-obesity with hypertension, obesity with normotension, and normal BMI with normotension.
- Serum concentrations of leptin, adiponectin, and visfatin were measured.
- Statistical analyses, including logistic regression, were employed to assess relationships with anthropometric and clinical parameters.
Main Results:
- Serum leptin levels were higher in non-obese individuals compared to obese individuals and higher in hypertensive individuals than normotensive individuals, though no direct relationship with hypertension was found.
- Serum adiponectin levels were significantly higher in the normal BMI and normotension group, with no significant differences among the other three groups.
- Serum visfatin levels were higher in hypertensive groups compared to normotensive groups, irrespective of obesity status.
- Logistic regression indicated increased hypertension risk associated with decreased adiponectin, increased waist circumference, and increased visfatin levels in obese women.
Conclusions:
- Adiponectin and visfatin levels demonstrate a correlation with obesity and blood pressure in females.
- These adipokines may play a significant role in the pathogenesis of hypertension, particularly in the context of female obesity.
- Further research is warranted to explore therapeutic strategies targeting these adipokines for hypertension management in obese women.
Objective:
This study was aimed to investigate the relationship between serum leptin, adiponectin, visfatin levels and obesity and essential hypertension in female subjects.
Methods:
According to BMI and blood pressure, 206 female participants enrolled were divided into four groups: group 1: obesity and hypertension (48 cases); group 2: non-obesity but hypertension (48 cases); group 3: obesity and normotension (56 cases) and group 4: normal BMI and blood pressure (54 cases). Serum leptin, adiponectin and visfatin levels were detected and their relationships to BMI, blood pressure and waist circumference were analysed.
Results:
Serum leptin levels were significantly higher in non-obese groups [group 2: (4.47 ± 1.26) ng/L, group 4: (3.73 ± 1.18) ng/L] than in obese groups [group 1: (2.97 ± 1.46) ng/L, group 3: (3.02 ± 1.18) ng/L], and higher in hypertension groups than in normotension groups. Serum adiponectin levels were obviously higher in group 4 [38.99 (19.75, 103.71) µg/L] than in the other three groups. There were no significant differences in adiponectin levels among group 1, 2 and 3. Serum levels of visfatin were lower in normotension groups [group 3: 3.19 (0.96, 9.45) ng/L; group 4:3.23 (1.92, 4.64) ng/L] than in hypertension groups [group 1: 3.84 (3.40, 5.35) ng/L; group 2: 3.75(1.63, 6.67) ng/L] irrespective of obesity. Logistics regression analysis showed that there was 1.6%, 8.3%, or 5.45% increased risk for hypertension for each 1 µg/L decrease in adiponectin, 1 cm increase in waist circumference, or 1 µg/L increase in visfatin level in obesity, respectively. No relationship could be viewed between leptin and hypertension.
Conclusions:
Adiponectin and visfatin levels were correlated with obesity and blood pressure in females. Both adipokines may play a crucial role in the development of hypertension in female obesity.
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