Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.8K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

2.5K
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The correlation analysis between sacral slope and the morphological characteristics of intervertebral disc, paraspinal muscle and pedicle in patients with degenerative lumbar spondylolisthesis].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
Same author

[Nomogram based on clinical and DCE-MRI characteristics for predicting the depth of myometrial invasion and grade of endometrioid endometrial carcinoma].

Zhonghua fu chan ke za zhi·2025
Same author

[Comparison of short-term outcomes of robotic and laparoscopic surgery for mid-low rectal cancer: a propensity matched analysis].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2024
Same author

[Analysis on incidence trend of meningococcal meningitis and major pathogenic serogroups of <i>Neisseria meningitidis</i> in China, 1990-2023].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2024
Same author

[Application of D-type stoma repair in parastomal hernia after permanent sigmoidostomy].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2024
Same author

[Feasibility study of R method of gastrojejunostomy applied to Billroth II digestive tract reconstruction after laparoscopic radical distal gastrectomy].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2023
Same journal

Jejunal Leiomyosarcoma in a Young Adult: Distinguishing from Gastrointestinal Stromal Tumor through Radiographic, Histologic, and Epidemiologic Analysis - A Case Report.

Gastrointestinal tumors·2024
Same journal

The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies.

Gastrointestinal tumors·2024
Same journal

Current Surgical Methods in Local Rectal Excision.

Gastrointestinal tumors·2024
Same journal

A Retrospective Study of Clinical Outcomes for Patients with Esophageal Cancer Who Were Treated with Radiotherapy Alone.

Gastrointestinal tumors·2024
Same journal

Investigation of Novel Urinary Biomarkers in Hepatocellular Carcinoma Risk in a Predominantly African American Population: A Case-Control Study.

Gastrointestinal tumors·2024
Same journal

Real-World Outcomes of FLOT versus CROSS Regimens for Patients with Oesophagogastric Cancers.

Gastrointestinal tumors·2023
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.1K

Colorectal Cancer: Basic and Translational Research.

J J Zhou1, S Zheng1

  • 1Department of Surgical Oncology, Second Affiliated Hospital, and The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.

Gastrointestinal Tumors
|December 18, 2015
PubMed
Summary
This summary is machine-generated.

Colorectal cancer (CRC) research advances understanding of tumor heterogeneity. Translational research strategies aim to improve patient outcomes through biomarker discovery and clinical validation.

Keywords:
Colorectal neoplasmsTherapeuticsTranslational medical research

More Related Videos

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
06:19

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Published on: July 18, 2017

10.9K
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

7.1K

Related Experiment Videos

Last Updated: Mar 28, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.1K
Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
06:19

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Published on: July 18, 2017

10.9K
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

7.1K

Area of Science:

  • Oncology
  • Translational Cancer Research

Background:

  • Colorectal cancer (CRC) remains a significant global health challenge, causing high mortality and morbidity.
  • Current CRC screening and treatment methods are traditional, despite progress in areas like cetuximab therapy, microsatellite instability detection, and understanding intrinsic CRC subtypes.

Purpose of the Study:

  • To highlight the role of translational cancer research in addressing CRC.
  • To outline the fundamental strategies employed in translational research for cancer patient benefit.

Main Methods:

  • Biomarker discovery.
  • Identification in xenografts.
  • Population-based verification.
  • Clinical validation.

Main Results:

  • Translational research drives progress in understanding human cancer heterogeneity.
  • Translational research aims to translate scientific discoveries into tangible patient benefits.

Conclusions:

  • The four core strategies of translational research are biomarker discovery, xenograft identification, population verification, and clinical validation.
  • These strategies are crucial for advancing cancer care and improving patient outcomes.