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Updated: Mar 28, 2026
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Carrier Deformability in Drug Delivery
Maria Jose Morilla, Eder Lilia Romero1
1Programa de Nanomedicinas, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal, B1876 BXD, Buenos Aires, Argentina. elromero@unq.edu.ar.
Current Pharmaceutical Design
|December 18, 2015
Summary
Highly deformable vesicles enhance drug penetration across skin without barrier disruption. These advanced drug carriers show significant promise for topical treatments and vaccinations, improving therapeutic outcomes.
Area of Science:
- Biomedical Engineering
- Materials Science
- Dermatology
Background:
- Deformable vesicles are crucial for enhancing transdermal drug delivery by improving skin penetration.
- Conventional liposomes have limitations in effectively delivering drugs across the skin barrier.
- Highly deformable vesicles offer superior performance for topical drug delivery compared to conventional liposomes.
Purpose of the Study:
- To provide an overview of the structural and mechanical properties of deformable vesicles.
- To present an updated review of preclinical applications of deformable vesicles for topical drug delivery.
Main Methods:
- Literature review focusing on structural and mechanical characteristics of deformable vesicles.
- Systematic search and analysis of preclinical studies utilizing deformable vesicles for various dermatological and systemic applications.
Main Results:
- Deformable vesicles demonstrate enhanced penetration into and across mammalian skin.
- These vesicles have been successfully applied in preclinical studies for joint diseases, skin cancer, atopic dermatitis, wound healing, psoriasis, scar treatment, and infections.
- Deformable vesicles show potential for topical vaccination strategies.
Conclusions:
- The structural and mechanical properties of deformable vesicles are key to their enhanced skin penetration capabilities.
- Deformable vesicles represent a versatile and effective platform for a wide range of topical drug delivery applications.
- Further preclinical development of deformable vesicles holds significant promise for advancing dermatological treatments and vaccination strategies.
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