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Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics in Healthy, Young Children

Anouk L M Eikendal1, Annemieke M V Evelein2, Cuno S P M Uiterwaal3

  • 1Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands (A.M.E.).

Journal of the American Heart Association
|December 18, 2015
PubMed

Insights

In healthy children, the chemokine RANTES is linked to early vascular changes, suggesting its role in pre-atherosclerosis. This finding offers insight into the early origins of atherosclerosis.

Area of Science:

  • Pediatric vascular health
  • Cardiovascular research
  • Inflammatory mediators

Background:

  • Atherosclerosis originates in childhood with inflammatory vascular alterations.
  • Chemokines are implicated as mediators of early vascular inflammation in atherosclerosis.
  • Limited research exists on specific chemokines in pediatric pre-atherosclerosis.

Purpose of the Study:

  • To investigate the relationship between specific chemokines and vascular characteristics in healthy children.
  • To examine if monocyte chemotactic protein 1 (MCP-1), regulated on activation normal T-cell expressed and secreted (RANTES), vascular cell adhesion molecule (VCAM), and intercellular adhesion molecule (ICAM) correlate with carotid artery parameters.

Main Methods:

  • Demographic, anthropometric, and plasma data were collected from 139 eight-year-old children.
  • Carotid intima-media thickness (CIMT), distensibility, and Young's Elastic Modulus (YEM) were measured using ultrasound.
  • Chemokine plasma levels were quantified using a multiplex assay, and associations were analyzed via multivariable linear regression.

Main Results:

  • Regulated on activation normal T-cell expressed and secreted (RANTES) was significantly associated with common carotid artery distensibility and Young's Elastic Modulus (YEM).
  • Increased RANTES levels correlated with decreased distensibility and increased YEM.
  • Monocyte chemotactic protein 1 (MCP-1), VCAM, and ICAM showed no significant associations with the measured vascular characteristics.

Conclusions:

  • RANTES plays a role in the development of pre-atherosclerotic vascular alterations in healthy young children.
  • These findings contribute to understanding the early-life origins of atherosclerosis.
  • Further research into chemokine involvement in pediatric vascular health is warranted.
Abstract

Keywords:
arteriosclerosisinflammationpediatricsrisk factorsultrasonography

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