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Antiviral benzofurans from Eupatorium chinense.

Wen-Jing Wang1, Lei Wang2, Zhong Liu3

  • 1Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao.

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Summary

Researchers isolated novel benzofuran dimers and a trimer from Eupatorium chinense roots. These compounds were tested for antiviral activity against respiratory syncytial virus (RSV).

Keywords:
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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Virology

Background:

  • Eupatorium chinense is a plant source of bioactive compounds.
  • Benzofuran derivatives are known for diverse biological activities.
  • Respiratory syncytial virus (RSV) poses a significant public health challenge.

Purpose of the Study:

  • To isolate and characterize novel benzofuran dimers and trimers from Eupatorium chinense.
  • To determine the absolute configurations of the isolated compounds.
  • To evaluate the in vitro antiviral activities of these compounds against RSV.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via spectroscopic data (NMR, MS) and X-ray diffraction.
  • Chiral High-Performance Liquid Chromatography (HPLC) for enantiomer separation.
  • In vitro antiviral assays against RSV.

Main Results:

  • Eleven novel benzofuran dimers ((+)- and (-)-dieupachinins A-E, dieupachinin F) and one trimer (trieupachinin A) were isolated.
  • Seven known compounds were also identified.
  • Absolute configurations were successfully determined.
  • Antiviral activity against RSV was evaluated for the isolated compounds.

Conclusions:

  • The study successfully identified and characterized new benzofuran natural products from Eupatorium chinense.
  • The isolated compounds represent potential leads for the development of novel antiviral agents against RSV.