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Detection of macrolide resistant Mycoplasma pneumoniae in England, September 2014 to September 2015

Rebecca J Brown1, Louissa Macfarlane-Smith, Sarah Phillips

  • 1Bacteriology Reference Department, Public Health England (PHE), London, United Kingdom.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|December 18, 2015
PubMed

Insights

Macrolide resistance is emerging in Mycoplasma pneumoniae, a common cause of childhood pneumonia. This study found resistance mutations in nearly 10% of cases in England and Wales, necessitating increased clinical awareness.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Mycoplasma pneumoniae is a significant cause of community-acquired pneumonia, especially in pediatric populations.
  • The rise in macrolide-resistant M. pneumoniae strains globally poses a therapeutic challenge due to limited alternative treatments.

Purpose of the Study:

  • To investigate the prevalence of macrolide resistance-conferring mutations in M. pneumoniae within clinical specimens from England and Wales.
  • To inform healthcare professionals about the presence of macrolide resistance in M. pneumoniae infections.

Main Methods:

  • Analysis of 43 clinical specimens positive for M. pneumoniae.
  • Detection of specific mutations associated with macrolide resistance.

Main Results:

  • Macrolide resistance-conferring mutations were identified in 9.3% of the analyzed M. pneumoniae clinical specimens.
  • The study period was from September 2014 to September 2015.

Conclusions:

  • The findings highlight the circulation of macrolide-resistant M. pneumoniae in England and Wales.
  • Increased clinical vigilance is recommended for patients with M. pneumoniae infections to ensure appropriate treatment strategies.
Keywords:
antimicrobial resistance pneumonia Mycoplasma pneumoniae Macrolide

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