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Updated: Mar 28, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Published on: June 3, 2014
War and peace: Factor VIII and the adaptive immune response
Maria T Georgescu1, Jesse D Lai1, Christine Hough1
1Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Abstract:
The development of neutralizing anti-factor VIII (FVIII) antibodies (inhibitors) remains a major challenge for FVIII replacement therapy in hemophilia A patients. The adaptive immune response plays a crucial role in the development and maintenance of inhibitors. In this review, we focus on our current understanding of FVIII interactions with cells of the adaptive immune system and the phenotype of the resultant response. Additionally, we examine both current and novel FVIII tolerance induction methods that function at the level of the adaptive immune response.
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