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Updated: Mar 28, 2026

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
Published on: March 14, 2021
3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Raghavendra Palankar1, Michael Glaubitz1, Ulrike Martens2
1ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.
Abstract:
3D micropillars generated by photolithography are used as a platform to probe by atomic force microscopy the mechanodynamics of human induced pluripotent stem cell-derived cardiomyocytes. 3D micropillars guide subcellular cytoskeletal modifications of cardiomyocytes and lead to biochemical changes altering beating rate, stiffness, and calcium dynamics of the cells.

