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Updated: Mar 28, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Understanding Metabolomics in Biomedical Research.

Su Jung Kim1, Su Hee Kim1, Ji Hyun Kim1

  • 1Biomedical Research Center, Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|December 18, 2015
PubMed
Summary

Metabolomics offers a direct link to organism phenotypes by analyzing metabolites, reflecting cellular activity. This review covers mass spectrometry techniques for metabolomics, aiding in understanding biological conditions and diseases.

Keywords:
LipidomicsMass spectrometryMetabolic profilingMetabolomicsTargeted metabolomics

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Area of Science:

  • Biochemistry
  • Systems Biology
  • Analytical Chemistry

Background:

  • Omics studies, including genomics and proteomics, provide insights into biological systems.
  • Metabolomics offers a direct link to phenotypes, reflecting biochemical activities and cellular metabolism.
  • Metabolites represent the molecular phenotype, easily translatable to biological conditions and disease states.

Purpose of the Study:

  • To review general strategies for mass spectrometry-based metabolomics.
  • To discuss targeted and nontargeted metabolomic and lipidomic analyses.
  • To briefly introduce biomedical applications of mass spectrometry-based metabolomics.

Main Methods:

  • Mass spectrometry-based metabolomics.
  • Targeted metabolomic and lipidomic analysis.
  • Nontargeted metabolomic and lipidomic analysis.

Main Results:

  • Metabolomics provides a direct readout of cellular biochemical activity.
  • Different mass spectrometry platforms offer distinct advantages and disadvantages for metabolomic analysis.
  • Metabolomics is a valuable tool for understanding biological states and diseases.

Conclusions:

  • Mass spectrometry-based metabolomics is a powerful approach for studying biological systems.
  • Understanding the strengths and weaknesses of different metabolomic platforms is crucial for experimental design.
  • Metabolomics has significant potential in biomedical research and diagnostics.