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Lower Urinary Tract Function in Spinocerebellar Ataxia 6
Fuyuki Tateno1, Ryuji Sakakibara1, Megumi Sugiyama1
1Department of Internal Medicine, Toho University, Sakura, JapanClinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, JapanDepartment of Urology, Toho University, Sakura, JapanDepartment of Neurology, Chiba University, Chiba, Japan.
Spinocerebellar ataxia type 6 (SCA6) can cause urinary frequency in 33% of patients. Neurogenic changes in sphincter electromyography were found in 63% of SCA6 patients studied.
Area of Science:
- Neurology
- Urology
Background:
- Spinocerebellar ataxia type 6 (SCA6) is a progressive neurodegenerative disorder.
- Lower urinary tract dysfunction is a potential but understudied complication of SCA6.
Purpose of the Study:
- To investigate lower urinary tract function in patients with spinocerebellar ataxia type 6 (SCA6).
Main Methods:
- Nine SCA6 patients underwent a urinary symptom questionnaire and urodynamics.
- Sphincter electromyography was performed on eight patients.
Main Results:
- Urinary symptoms, including frequency, were reported by 56% of patients.
- Urodynamic abnormalities included detrusor overactivity (11%) and weak detrusor (22%).
- Neurogenic changes were detected in sphincter electromyography in 63% of patients.
Conclusions:
- Lower urinary tract symptoms and neurogenic changes are present in SCA6 patients.
- Findings suggest a link between cerebellar/spinal cord pathology and urinary dysfunction in SCA6.
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