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Male Lower Urinary Tract Symptoms: Hypertension as a Risk Factor for Storage Symptoms, but Not Voiding Symptoms

Hideaki Ito1, Takashi Yoshiyasu1, Osamu Yamaguchi1

  • 1Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, JapanAstellas Pharma Inc., Tokyo, JapanDivision of Bioengineering and LUTD Research, Nihon University School of Engineering, Koriyama, Japan.

Lower Urinary Tract Symptoms
|December 18, 2015
PubMed

Insights

Hypertension (HT) is linked to more frequent and severe lower urinary tract symptoms (LUTS) in men. Tamsulosin effectively treats LUTS, with a notable impact on storage symptoms in hypertensive patients.

Area of Science:

  • Urology
  • Cardiology
  • Geriatrics

Background:

  • Lower urinary tract symptoms (LUTS) and hypertension (HT) are common in aging men.
  • The relationship between LUTS and HT requires further investigation.
  • The impact of alpha-blockers on LUTS in hypertensive patients is not fully understood.

Purpose of the Study:

  • To investigate the association between male LUTS and HT.
  • To evaluate the efficacy of alpha-1 blockers (tamsulosin) in managing LUTS, particularly in men with HT.

Main Methods:

  • A multicenter survey involving 10,744 men with LUTS.
  • 12-week tamsulosin administration (0.2 mg/day) in 4,828 men.
  • Assessment using International Prostate Symptom Score (IPSS) and Quality of Life (QOL) surveys pre- and post-treatment.

Main Results:

  • Hypertension (25.9%) was a more prevalent comorbidity than diabetes or cardiac disease.
  • HT prevalence increased with the severity of urinary frequency and nocturia.
  • Tamsulosin improved storage and voiding symptoms in men over 40.
  • Tamsulosin showed a more prominent effect on storage symptoms in patients with HT.

Conclusions:

  • Hypertension is a risk factor for increased frequency and severity of storage LUTS.
  • HT influences the efficacy of alpha-1 blockers in managing LUTS.
  • Tamsulosin effectively improves LUTS, with specific benefits for storage symptoms in hypertensive men.
Abstract

Keywords:
hypertensionlower urinary tract symptomstorage symptomα1-blocker

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