Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

3.5K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
3.5K
Physiology of Urine Formation01:24

Physiology of Urine Formation

16.5K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
16.5K
Disorders of the Urinary System01:20

Disorders of the Urinary System

1.9K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.9K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

2.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
2.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.2K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.2K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Energy Shockwave Therapy for Interstitial Cystitis/Bladder Pain Syndrome From Bench to Clinic.

International journal of urology : official journal of the Japanese Urological Association·2026
Same author

Rapid <i>N</i>-Trifluoromethylsulfinylation of Sulfoximines in Batch and Flow.

The Journal of organic chemistry·2026
Same author

Early Prostate-Specific Antigen Dynamics as Predictors of Treatment Response and Survival Outcomes in Patients with Castration-Resistant Prostate Cancer and Bone Metastases Undergoing Radium-223 Therapy.

The world journal of men's health·2026
Same author

Efficacy of behavioral therapy and different dosages of mirabegron for the treatment of male overactive bladder patients.

International urology and nephrology·2026
Same author

Assessing multiple chatGPT versions on novel content in the Taiwan urology board examination: accuracy, speed, and domain-specific performance.

World journal of urology·2026
Same author

Overweight status predicts improved overall survival after radical nephroureterectomy for upper tract urothelial carcinoma.

The Canadian journal of urology·2026
Same journal

Pretreatment Factors Associated With Pain Improvement After Cernitin Pollen Extract Therapy in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Post Hoc Analysis.

Lower urinary tract symptoms·2026
Same journal

The Influence of Age, BMI, and Parity on 3D MRI-Derived Morphology of Pelvic Floor Muscle and Levator Ani Hiatus in Women With Stress Urinary Incontinence.

Lower urinary tract symptoms·2026
Same journal

Tizanidine as an Adjunct to Alpha-Blockers in Adults With Dysfunctional Voiding/Poor Relaxation of the External Sphincter: A Retrospective Review.

Lower urinary tract symptoms·2026
Same journal

Chronic Bladder Ischemia Enhances Mechanosensitive Afferent C-Fiber Activity: Insights From a Newly Developed Female Rat Model.

Lower urinary tract symptoms·2026
Same journal

Role of Free-Flow Uroflowmetry as an Adjunct in Management of Urinary Tract Dysfunction for Children "At-Risk" for Neurogenic Bladder.

Lower urinary tract symptoms·2026
Same journal

BOOI-Defined Obstruction Stratifies Early Outcomes After ThuLEP in Men With Detrusor Underactivity: A Retrospective Complete-Case Cohort Study.

Lower urinary tract symptoms·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K

Pathophysiology of Overactive Bladder.

En Meng1, Wei-Yu Lin1, Wei-Chia Lee1

  • 1Department of Urology, Tri-Service General Hospital, National Defense Medical Center, TaipeiDepartment of Urology, Chia Yi Chang Gung Memorial Hospital, ChiayiDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Lower Urinary Tract Symptoms
|December 18, 2015
PubMed
Summary
This summary is machine-generated.

Overactive bladder syndrome (OAB) involves urinary urgency and frequency. Detecting urinary proteins like NGF may reveal new diagnostic biomarkers for OAB pathophysiology.

Keywords:
inflammationmetabolic syndromeoveractive bladderpathophysiologyurothelium

More Related Videos

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

7.8K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.5K

Related Experiment Videos

Last Updated: Mar 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K
A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

7.8K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.5K

Area of Science:

  • Urology
  • Nephrology
  • Biochemistry

Background:

  • Overactive bladder syndrome (OAB) is a common condition affecting quality of life.
  • OAB symptoms include urinary frequency, nocturia, and urgency, with or without incontinence.
  • Potential causes of OAB involve myogenic, neurogenic, and urotheliogenic factors.

Purpose of the Study:

  • To explore the underlying pathophysiology of overactive bladder syndrome.
  • To identify potential novel diagnostic biomarkers for OAB.

Main Methods:

  • Review of proposed etiological factors for OAB.
  • Discussion of how metabolic derangements, bladder outlet obstruction, and inflammation contribute to OAB.
  • Consideration of urinary protein detection for diagnostic advancement.

Main Results:

  • Disturbances in myogenic, neurogenic, or urotheliogenic factors can cause OAB.
  • Increased nerve and detrusor muscle excitability, altered urothelial function are implicated.
  • Urinary proteins such as NGF, PGE2, and proinflammatory chemokines are potential indicators.

Conclusions:

  • Understanding OAB pathophysiology can be advanced by studying these factors.
  • Urinary protein detection may offer novel diagnostic biomarkers for OAB.