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Updated: Mar 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Pathophysiology of Overactive Bladder
En Meng1, Wei-Yu Lin1, Wei-Chia Lee1
1Department of Urology, Tri-Service General Hospital, National Defense Medical Center, TaipeiDepartment of Urology, Chia Yi Chang Gung Memorial Hospital, ChiayiDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Abstract:
Overactive bladder syndrome (OAB), characterized by urinary frequency, nocturia and urgency with or without incontinence, is a widespread medical condition with significant impact on quality of life. Three main factors have been proposed regarding the cause of OAB: myogenic, neurogenic and urotheliogenic. Disturbance of any of the three factors or a combination of these factors can attribute to OAB. Metabolic derangement, bladder outlet obstruction and inflammation can increase the excitability of nerve, detrusor muscle and alter the sensory and barrier functions of the urothelium. The detection of proteins in the urine such as NGF, PGE2, and proinflammatory chemokines may advance our understanding of the pathophysiology of OAB and offer novel diagnostic biomarkers of OAB.
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