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Antithrombin: anti-inflammatory properties and clinical applications
Jerrold H Levy1, Roman M Sniecinski, Ian J Welsby
1Jerrold H. Levy, MD, FAHA, FCCM, DUMC 3094, Durham, NC 27710, USA, Tel.: +1 919 681 6614, Fax: +1 919 681 8994,
Thrombosis and Haemostasis
|December 18, 2015
Summary
Antithrombin (AT) concentrate has anticoagulant and anti-inflammatory effects. It helps restore hemostasis and reduce inflammation in AT deficiency, showing potential for treating inflammatory conditions.
Area of Science:
- Biochemistry
- Immunology
- Hematology
Background:
- Coagulation and inflammation pathways are interconnected.
- Natural anticoagulants like antithrombin (AT) inhibit inflammation.
- Inflammation can impair anticoagulation, leading to coagulation disorders like sepsis.
Purpose of the Study:
- To review the mechanisms and clinical applications of AT concentrate.
- To explore AT's role in critically ill patients and perioperative management.
- To highlight AT's anti-inflammatory properties beyond anticoagulation.
Main Methods:
- Review of existing literature on antithrombin (AT) concentrate.
- Analysis of AT's mechanisms of action in coagulation and inflammation.
- Discussion of clinical evidence for AT concentrate use.
Main Results:
- AT concentrate restores hemostasis and reduces inflammation in AT deficiency.
- AT inhibits pro-inflammatory mediators via coagulation-dependent and -independent pathways.
- Evidence supports AT concentrate as a therapeutic agent in inflammatory settings.
Conclusions:
- AT concentrate is effective in managing hereditary and acquired AT deficiency.
- AT's anti-inflammatory properties offer therapeutic potential in inflammatory conditions.
- AT concentrate may be valuable in treating thrombotic states with an inflammatory component.
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