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RNA Systems Biology for Cancer: From Diagnosis to Therapy

Raheleh Amirkhah1, Ali Farazmand1, Olaf Wolkenhauer2,3

  • 1Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.

Methods in Molecular Biology (Clifton, N.J.)
|December 18, 2015
PubMed

Insights

Advances in RNA research reveal numerous non-coding RNAs (ncRNAs) crucial for disease regulation, particularly in cancer. This highlights their potential as diagnostic and therapeutic tools in RNA systems medicine.

Area of Science:

  • Biomedical Research
  • Genomics
  • Cancer Biology

Background:

  • High-throughput omics data generation has renewed focus on RNA species.
  • International projects like ENCODE and GENCODE have identified thousands of functional non-coding RNAs (ncRNAs).
  • Many ncRNAs are implicated in the development and progression of human diseases, especially cancer.

Purpose of the Study:

  • To elaborate on the state of the art in RNA systems biology.
  • To review and provide a perspective on clinical applications of ncRNAs in cancer.
  • To discuss an integrative RNA systems medicine approach.

Main Methods:

  • Interdisciplinary studies integrating bioinformatics, systems biology, and biotechnology.
  • Characterization of ncRNA roles in human cancers.
  • Review of current literature and clinical applications.

Main Results:

  • Identification of numerous functional ncRNAs with regulatory roles.
  • Established links between ncRNAs and human disease emergence and progression.
  • Development of ncRNA-based tools for cancer diagnosis, monitoring, and treatment.

Conclusions:

  • ncRNAs play a significant role in cancer biology.
  • RNA systems biology offers a new toolkit for cancer management.
  • An integrative RNA systems medicine approach is emerging for clinical practice.
Keywords:
Bioinformatics toolsBiomarker predictionIntegrative workflowsNon-coding RNASystems biology methodsTherapeutic target identificationmicroRNA

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