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Related Experiment Video

Updated: Mar 28, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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Published on: July 28, 2023

The Association between Atopic Disorders and Keloids: A Case-control Study.

Enes Hajdarbegovic¹, Annemieke Bloem¹, Deepak Balak¹

¹Department of Dermatology and Venerology, Erasmus Medical Centre, Rotterdam, Netherlands.

Indian Journal of Dermatology

|December 18, 2015

Summary

Keloids may be linked to asthma, but not atopic eczema or hay fever. This research suggests asthma might be a risk factor for developing keloid scars.

Keywords:

Asthma atopic dermatitis atopy fibrosis keloid scar

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Area of Science:

Dermatology
Allergology
Immunology

Background:

Keloids and atopic disorders share common inflammatory pathways involving T-helper cell 2 cytokines.
Understanding these shared pathways may reveal links between keloid formation and atopic conditions.

Purpose of the Study:

To investigate potential associations between keloid formation and atopic eczema, asthma, and hay fever.
To determine if atopic conditions are risk factors for keloid development.

Main Methods:

A case-control study involving 131 keloid patients and 258 controls.
Data collected via questionnaires on lifetime prevalence of atopic eczema, asthma, and hay fever, referencing ECRHS and ISAAC protocols.

Main Results:

Asthma prevalence was lower in keloid patients, but inhalator use for asthma showed a significant association.
Adjusted analysis indicated asthmatics using inhalators had an increased odds ratio (4.44) for keloid presence.
No consistent associations were found between keloids and atopic eczema or hay fever.

Conclusions:

Keloids appear to be strongly associated with atopic asthma, particularly in patients using inhalators.
Atopic eczema and hay fever do not show a significant correlation with keloid development.
Further research is recommended to validate atopic asthma as a risk factor for keloid scars.