Related Experiment Video

Updated: Mar 28, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

The relationship between serum bilirubin concentration and coronary artery ectasia

Mehmet Demir1, Canan Demir2, Serdar Keçeoğlu1

  • 1Cardiology Department, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|December 18, 2015
PubMed

Insights

Serum bilirubin levels were significantly lower in patients with coronary artery ectasia (CAE) compared to controls. This finding suggests a potential link between lower bilirubin and the development of CAE.

Area of Science:

  • Cardiology
  • Biochemistry
  • Vascular Biology

Background:

  • The underlying causes of coronary artery ectasia (CAE) remain unclear, with potential links to arteritis, endothelial dysfunction, and atherothrombosis.
  • Elevated serum bilirubin is known to possess anti-inflammatory and anti-proliferative effects on vascular smooth muscle cells, and is associated with cardiovascular disease.
  • The specific relationship between serum bilirubin levels and CAE has not been previously established.

Purpose of the Study:

  • To investigate and compare serum bilirubin concentrations between individuals diagnosed with coronary artery ectasia and a control group.
  • To explore potential associations between bilirubin levels and the presence of CAE.

Main Methods:

  • A case-control study involving 50 patients with CAE and 30 healthy controls.
  • Demographic data, routine biochemical tests, and complete blood counts were collected for all participants.
  • Serum bilirubin levels (total, direct, and indirect) were measured and compared between the CAE and control groups.

Main Results:

  • No significant differences in basic demographic characteristics were observed between the CAE patients and the control group.
  • Serum levels of total, direct, and indirect bilirubin were found to be significantly lower in patients with CAE compared to controls (p<0.001 for all).

Conclusions:

  • This study demonstrates a significant association between lower serum bilirubin levels and coronary artery ectasia.
  • Reduced serum bilirubin may play a role in the pathophysiology of CAE.
Abstract

Keywords:
bilirubincoronary artery ectasiaendothelial dysfunctioninflammation

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

17.2K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.3K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
421
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
955
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
611
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.6K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
745