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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Remodeling and Repair01:31

Bone Remodeling and Repair

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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
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[RESEARCH PROGRESS OF OSTEOCLASTS FUNCTION BEYOND BONE RESORPTION].

Chaorui Wu, Jie Zhang, Jing Tian

    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
    |December 19, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Osteoclasts (OCs) do more than resorb bone; they regulate bone formation, stem cell function, and blood vessel growth. Further research is needed to understand their full role in health and disease.

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    Area of Science:

    • Bone Biology
    • Hematopoiesis
    • Angiogenesis

    Background:

    • Osteoclasts (OCs) are traditionally known for their role in bone resorption.
    • Emerging evidence suggests OCs possess functions beyond their classical role in bone remodeling.

    Purpose of the Study:

    • To review and summarize the multifaceted functions of osteoclasts (OCs) beyond bone resorption.
    • To explore the implications of these novel functions in bone biology and related physiological processes.

    Main Methods:

    • Comprehensive literature review of studies investigating osteoclast (OC) functions.
    • Analysis and synthesis of findings related to OC roles in bone formation, stem cell regulation, and angiogenesis.

    Main Results:

    • Osteoclasts (OCs) actively regulate bone formation via growth factors and cell signaling.
    • OCs are crucial for hematopoietic stem cell niche formation, mobilization, and maintenance.
    • OCs also play a significant role in regulating angiogenesis.

    Conclusions:

    • Osteoclast (OC) functions extend beyond bone resorption, impacting bone formation, stem cell biology, and angiogenesis.
    • Further investigation is required to fully elucidate the mechanisms of OC-mediated hematopoiesis and angiogenesis.
    • Understanding these complex OC roles may lead to novel therapeutic strategies for OC-related diseases.