Sixteen years of experience with persistent chylothorax in children
Alessio Pini Prato1, Gian L Bava2, Pietro Dalmonte2
1Department of Pediatric Surgery, Giannina Gaslini Institute, Genoa, Italy - alessiopiniprato@ospedale-gaslini.ge.it.
Insights
Persistent chylothorax in children can be treated surgically. Thoracic duct ligation is an effective option for unresponsive cases, especially right-sided effusions with high output, preventing relapses.
Area of Science:
- Pediatric Surgery
- Thoracic Surgery
- Critical Care Medicine
Background:
- Persistent chylothorax in children is a rare condition.
- Conservative management is standard, but surgical intervention is necessary for treatment failures.
- Idiopathic chylothorax requires effective surgical strategies.
Purpose of the Study:
- To present surgical treatment outcomes for persistent idiopathic chylothorax.
- To evaluate the efficacy of thoracic duct ligation in managing this condition.
Main Methods:
- Retrospective analysis of 9 pediatric patients undergoing surgery for persistent chylothorax (1994-2010).
- Procedures included pleurodesis and thoracic duct ligation.
- Data on patient demographics, effusion laterality, and treatment outcomes were collected.
Main Results:
- Thoracic duct ligation led to complete cessation of chylothorax within a median of 5 days.
- Pleurodesis cessation took a median of 10 days, with 3 cases failing and requiring subsequent ligation.
- No relapses occurred in patients who underwent thoracic duct ligation.
Conclusions:
- Thoracic duct ligation is an effective treatment for persistent, unresponsive chylothorax in children.
- For right-sided effusions with high output (>20 mL/kg), thoracic duct ligation may be a primary surgical choice.
Background:
Persistent chylothorax in children is rare. Conservative management represents the gold standard but, in case of failure (persistent effusion or relapse), surgery must be considered. This paper aimed at presenting our series of patients who underwent surgical treatment of persistent idiopathic chylothorax and at discussing the role of thoracic duct ligation in its management.
Methods:
We included all patients who underwent surgery for persistent chylothorax in the period between January 1994 and January 2010.
Results:
Nine patients were included (median age 25 months). Five patients had primitive or idiopathic chylothorax. Five patients had right-sided chylothorax, 3 left-sided, and 1 bilateral. Pleurodesis was applied to 8 patients (bilateral in one) and thoracic duct ligation to 4 patients for a total of 12 procedures in 9 patients. Complete cessation occurred within a median of 5 days (range 2 to 10) after thoracic duct ligation and 10 days (range 4 to 25) after pleurodesis. In 3 patients (all with right sided effusion and a median daily output higher than 20 ml/kg) pleurodesis failed and thoracic duct ligation was subsequently required to definitively treat chylothorax. Conversely, 5 patients were effectively treated with pleurodesis and 1 with thoracic duct ligation alone. Regardless of previous procedures, none of the patients who underwent thoracic duct ligation experienced relapses.
Conclusions:
Although based on a small number of patients, our experience confirmed that thoracic duct ligation represents an effective therapeutic option for persistent unresponsive chylothorax. In cases of right sided effusion with high output rate (>20 mL/kg) thoracic duct ligation might be considered as first choice treatment.
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