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Related Experiment Videos

An update on digoxin.

J A Stone1, S J Soldin

  • 1Children's Hospital National Medical Center Research Foundation, Washington, DC 20010.

Clinical Chemistry
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

This review covers recent advancements in therapeutic drug monitoring for digoxin. It addresses methods to reduce assay interference and explores alternative analytical techniques and clinical considerations for digoxin therapy.

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Area of Science:

  • Pharmacology
  • Clinical Chemistry
  • Analytical Chemistry

Background:

  • Digoxin is a critical medication for heart failure and arrhythmias.
  • Accurate therapeutic drug monitoring (TDM) of digoxin is essential for efficacy and safety.
  • Immunoassays for digoxin are susceptible to interference from various factors.

Purpose of the Study:

  • To review recent developments in digoxin TDM.
  • To discuss strategies for minimizing interference in digoxin immunoassays.
  • To explore alternative analytical methods and clinical applications of digoxin monitoring.

Main Methods:

  • Review of recent literature on digoxin TDM.
  • Discussion of interference reduction strategies in immunoassays.
  • Overview of alternative analytical techniques including receptor assays and high-performance liquid chromatography (HPLC).

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Main Results:

  • Several strategies exist to decrease interference from digoxin metabolites, digoxin-like factors, and spironolactone metabolites.
  • Alternative methods like receptor assays and HPLC offer improved specificity.
  • Digoxin-like factors, drug-drug interactions, and drug redistribution impact digoxin levels and monitoring.

Conclusions:

  • Optimized digoxin TDM requires addressing assay interferences and considering alternative methods.
  • Understanding factors affecting digoxin levels is crucial for effective patient management.
  • Forensic and clinical implications of digoxin monitoring are continuously evolving.