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Biomedical applications of nisin.
J M Shin1,2, J W Gwak1, P Kamarajan1
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Journal of Applied Microbiology
|December 19, 2015
Summary
Nisin, a bacteriocin, is expanding from food preservation to biomedical uses. It shows antimicrobial, anti-biofilm, and anti-cancer properties, offering potential clinical applications against resistant bacteria and tumors.
Area of Science:
- Microbiology
- Biochemistry
- Pharmacology
Background:
- Nisin is a Type A lantibiotic produced by Lactococcus and Streptococcus species.
- Initially used as a food biopreservative, nisin has undergone extensive research for novel applications.
- Nisin is FDA-approved and recognized for its safety and potential clinical utility.
Purpose of the Study:
- To review and compare studies on nisin's antimicrobial and biomedical applications.
- To explore nisin's potential beyond its traditional role in food preservation.
- To provide insights into the future biomedical prospects of nisin.
Main Methods:
- Literature review of studies on nisin's properties and applications.
- Analysis of research on nisin's antimicrobial activity against various pathogens.
- Examination of studies investigating nisin's effects on biofilms, immune responses, and cancer cells.
Main Results:
- Nisin exhibits antimicrobial activity against Gram-positive and Gram-negative pathogens, including drug-resistant strains like MRSA.
- Nisin demonstrates anti-biofilm properties and synergistic effects with conventional drugs.
- Emerging evidence suggests nisin possesses immunomodulatory roles and selective cytotoxicity towards cancer cells.
Conclusions:
- Nisin's applications have significantly advanced into the biomedical field.
- Nisin shows promise as a therapeutic agent against infectious diseases and cancer.
- Further research into nisin's mechanisms and clinical efficacy is warranted for future biomedical applications.
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