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Related Experiment Video

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MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Essential tremor.

Theresa Ann Zesiewicz1, Sheng-Han Kuo

  • 1University of South Florida, Tampa, FL, US.

BMJ Clinical Evidence
|December 19, 2015
PubMed
Summary
This summary is machine-generated.

This systematic overview evaluates drug treatments for essential tremor, a common movement disorder. It categorizes the efficacy of 13 interventions, providing insights into their effectiveness and safety for patients.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Essential tremor is a prevalent movement disorder affecting 0.4% to 3.9% of the global population.
  • It is one of the most common neurological conditions encountered worldwide.

Purpose of the Study:

  • To systematically review the effects of drug treatments for essential tremor of the hand.
  • To provide an evidence-based overview of pharmacological interventions.

Main Methods:

  • A systematic overview was conducted, searching major databases including Medline and Embase up to January 2014.
  • Included studies were screened, appraised, and data were synthesized, with a GRADE evaluation performed for 11 PICO combinations.
  • Two randomized controlled trials (RCTs) were added in this update.

Main Results:

  • 56 studies were initially retrieved, with 13 full publications undergoing detailed evaluation.
  • The review assessed the effectiveness and safety of numerous drug treatments.

Conclusions:

  • The efficacy of 13 interventions for essential tremor was categorized.
  • Interventions evaluated include alprazolam, various beta-blockers (including propranolol), botulinum A toxin, clonazepam, diazepam, gabapentin, levetiracetam, lorazepam, phenobarbital, primidone, sodium oxybate, and topiramate.