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Systemic Coronaviral Disease in 5 Ferrets.

Christopher R Autieri1, Cassandra L Miller2, Kathleen E Scott1

  • 1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Comparative Medicine
|December 19, 2015
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Summary

Systemic coronaviral disease in ferrets is increasingly reported. This case report highlights clinical signs, pathology, and diagnosis, emphasizing its importance in young ferrets with abdominal masses.

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Area of Science:

  • Veterinary Pathology
  • Infectious Diseases
  • Comparative Medicine

Background:

  • Systemic coronaviral disease in ferrets (Mustela putorius furo) is an emerging condition.
  • The disease shares similarities with the dry form of feline infectious peritonitis.
  • Prevalence has increased in scientific literature over the past decade.

Purpose of the Study:

  • To describe clinical signs, pathological findings, and diagnostic methods for systemic coronaviral disease in ferrets.
  • To illustrate the importance of considering this infection in differential diagnoses.
  • To report on a cohort of five affected ferrets.

Main Methods:

  • Clinical case review of five ferrets.
  • Pathological examination of affected animals.
  • Immunohistochemistry using the FIPV3-70 monoclonal antibody for diagnosis.

Main Results:

  • Detailed description of clinical signs and gross/histopathological findings.
  • Successful diagnosis confirmed via immunohistochemistry.
  • Affected ferrets included both laboratory-housed and privately referred cases.

Conclusions:

  • Systemic coronaviral disease is an important differential diagnosis in young, debilitated ferrets presenting with abdominal masses.
  • Immunohistochemistry with FIPV3-70 is a key diagnostic tool.
  • Increased recognition and reporting of this disease are noted.