Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Resonance and Hybrid Structures02:16

Resonance and Hybrid Structures

29.0K
According to the theory of resonance, if two or more Lewis structures with the same arrangement of atoms can be written for a molecule, ion, or radical, the actual distribution of electrons is an average of that shown by the various Lewis structures.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.
29.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

15.0K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
15.0K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.6K
4.6K
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

4.1K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
4.1K
Resonance02:52

Resonance

70.6K
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
70.6K
Structural Classification of Joints01:20

Structural Classification of Joints

8.7K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TBM preferred to AlphaFold 3 for functional models of insect odorant receptors.

Computational and structural biotechnology journal·2026
Same author

Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration.

Briefings in bioinformatics·2025
Same author

Biological databases in the age of generative artificial intelligence.

Bioinformatics advances·2025
Same author

Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions.

Scientific reports·2024
Same author

Pseudonormal Morphology of Salivary Gland Adenoid Cystic Carcinoma Cells Subverts the Antitumor Reactivity of Immune Cells: A Tumour-Cell-Based Initiation of Immune Evasion.

Cancer reports (Hoboken, N.J.)·2024
Same author

iBio-GATS-A Semi-Automated Workflow for Structural Modelling of Insect Odorant Receptors.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Mar 28, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.8K

Discrete structural features among interface residue-level classes.

Gopichandran Sowmya, Shoba Ranganathan

    BMC Bioinformatics
    |December 19, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Protein-protein interactions are driven by distinct interface polarities. Most complexes show lower interface polarity, but a significant subset exhibits higher polarity, revealing diverse binding forces.

    More Related Videos

    Single Particle Cryo-Electron Microscopy: From Sample to Structure
    11:52

    Single Particle Cryo-Electron Microscopy: From Sample to Structure

    Published on: May 29, 2021

    9.9K
    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
    09:51

    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

    Published on: July 16, 2017

    16.2K

    Related Experiment Videos

    Last Updated: Mar 28, 2026

    Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
    07:08

    Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

    Published on: July 14, 2015

    7.8K
    Single Particle Cryo-Electron Microscopy: From Sample to Structure
    11:52

    Single Particle Cryo-Electron Microscopy: From Sample to Structure

    Published on: May 29, 2021

    9.9K
    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
    09:51

    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

    Published on: July 16, 2017

    16.2K

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Computational Biology

    Background:

    • Protein-protein interactions (PPIs) are fundamental to cellular functions.
    • Understanding PPIs requires analyzing the interfaces of protein complexes.
    • Investigating these interfaces helps decipher the forces driving molecular binding.

    Purpose of the Study:

    • To estimate the relative difference in polar residues between protein surfaces and interfaces.
    • To understand the predominant forces driving protein-protein binding.
    • To classify protein complexes based on interface polarity characteristics.

    Main Methods:

    • Analyzed a non-redundant heterodimer dataset of 278 protein complexes.
    • Calculated the percentage of polar residues on protein surfaces versus interfaces.
    • Utilized comprehensive analyses including interface area, polarity, solvation free energy, binding energy, and charged residue abundance.

    Main Results:

    • Approximately 60% of complexes (Class A) had greater surface polarity than interface polarity.
    • Around 40% of complexes (Class B) showed higher interface polarity than surface polarity (p-value < 1.66E-45).
    • Interface features like area, polarity, solvation energy, binding energy, and charged residue abundance distinguished Class A and Class B complexes.

    Conclusions:

    • Class A complexes exhibit non-polar interfaces, typical of classical interactions.
    • Class B complexes display polar interfaces, similar to protein surfaces, indicating diverse binding mechanisms.
    • Five key physicochemical features discriminate between these interface classes, aiding in predicting protein-protein binding and designing drugs.