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Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies
1Neuromuscular Diseases Unit, Neurology Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Background:
Carpal tunnel syndrome is the most common type of peripheral entrapment neuropathy.
Patients & Methods:
We performed an exploratory, open-label, multicenter, observational study of 48 patients with peripheral entrapment neuropathy. Patients received a daily capsule of uridine monophosphate, folic acid + vitamin B12 for 2 months and were evaluated using the Pain DETECT questionnaire.
Results:
The global score for pain decreased from 17.3 ± 5.9 at baseline to 10.3 ± 6.1 at the final evaluation (p < 0.001). Concomitant analgesic and anti-inflammatory treatment was stopped or the dose reduced in 77.4% of patients.
Conclusion:
Uridine monophosphate + folic acid + vitamin B12 reduced total pain score, intensity and characterization of pain and associated symptoms. These results should be tested in a well-designed, adequately powered randomized controlled trial.
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