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Risk factors of different congenital heart defects in Guangdong, China

Yanqiu Ou1, Jinzhuang Mai1, Jian Zhuang2

  • 1Department of Cardiovascular Disease Epidemiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital (Guangdong Academic of Medical Science), Guangzhou, Guangdong, China.

Pediatric Research
|December 19, 2015
PubMed

Insights

Maternal environmental exposures and perinatal conditions are key risk factors for congenital heart defects (CHDs) in Southern China. Different risk factors are associated with isolated versus multiple CHDs.

Area of Science:

  • Cardiology
  • Public Health
  • Environmental Health

Background:

  • Limited research exists on congenital heart defect (CHD) risk factors in China.
  • This study compares risk factors for isolated vs. multiple CHDs and among CHD subtypes.

Purpose of the Study:

  • To identify and compare risk factors for congenital heart defects (CHDs) in Guangdong, Southern China.
  • To investigate differences in risk factors between isolated and multiple CHDs and among CHD subtypes.

Main Methods:

  • Population-based case-control study.
  • Included 4,034 pairs of infants from the Guangdong Registry of CHD study (2004-2013).
  • Utilized multivariate logistic regression to calculate adjusted odds ratios (ORs).

Main Results:

  • Maternal exposures (renovated rooms, traffic proximity, paternal smoking, manual labor) and paternal alcohol intake were associated with CHDs.
  • Maternal perinatal diseases (fever, diabetes, influenza, threatened abortion), antibiotic use, advanced maternal age, and low socioeconomic status were also linked to CHDs.
  • Isolated and multiple CHDs exhibited distinct risk factor profiles, while CHD subtypes shared common factors.

Conclusions:

  • Maternal environmental exposures, occupation, perinatal diseases, and medication use are significant risk factors for CHDs in Southern China.
  • Etiological factors may differ between isolated and multiple congenital heart defects.
Abstract

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