Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multistage models for carcinogenesis.

D A Freedman1, W C Navidi

  • 1Statistics Department, University of California, Berkeley 94720.

Environmental Health Perspectives
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Striatal removal without previous cortical ablation; release, disorientation, metabolic disturbance.

Federation proceedings·2010
Same author

The synthesis and characterization of potassium 2,2'-bipyridinetetranitroruthenate.

Inorganic chemistry·2001
Same author

Convenient synthesis of tris-heteroleptic ruthenium(II) polypyridyl complexes.

Inorganic chemistry·2001
Same author

Salt and blood pressure. Conventional wisdom reconsidered.

Evaluation review·2001
Same author

Correlation bias in U.S. census adjustment.

Evaluation review·2000
Same author

The swine flu vaccine and Guillain-Barré syndrome. A case study in relative risk and specific causation.

Evaluation review·2000
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

The multistage model for cancer development fits some human and animal data but not all. It may not fully represent the complex biological processes underlying cancer, particularly in ex-smokers.

Area of Science:

  • Epidemiology
  • Biostatistics
  • Cancer Research

Background:

  • The multistage model is a theoretical framework used to explain cancer incidence over time.
  • Understanding cancer development is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To evaluate the applicability of the multistage model to diverse human and animal cancer data.
  • To identify limitations of the multistage model in capturing biological nuances of carcinogenesis.

Main Methods:

  • Analysis of human and animal epidemiological data sets.
  • Comparison of observed cancer incidence patterns with model predictions.
  • Statistical assessment of model fit.

Main Results:

Related Experiment Videos

  • The multistage model demonstrated good fit for certain datasets.
  • Significant deviations were observed with human lung cancer data, especially concerning ex-smokers.
  • The model's predictions did not consistently align with observed risk patterns.

Conclusions:

  • The multistage model offers a useful family of curves for fitting cancer incidence data.
  • The model's assumptions may not fully encompass the biological complexity of cancer development.
  • Further research is needed to refine models of carcinogenesis.