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Updated: Mar 28, 2026

Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
Adipose tissue and atherosclerosis
R Poledne1, I Králová Lesná, S Čejková
1Laboratory for Atherosclerosis Research, Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic. rudolf.poledne@ikem.cz.
Abstract:
High-energy intake which exceeds energy expenditure leads to the accumulation of triglycerides in adipose tissue, predominantly in large-size adipocytes. This metabolic shift, which drives the liver to produce atherogenic dyslipidemia, is well documented. In addition, an increasing amount of monocytes/macrophages, predominantly the proinflammatory M1-type, cumulates in ectopic adipose tissue. The mechanism of this process, the turnover of macrophages in adipose tissue and their direct atherogenic effects all remain to be analyzed.
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