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Updated: Mar 28, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Expression Pattern of p27 Protein in Primary Gastric Lymphomas
Purpose:
To investigate the expression pattern of p27 protein in primary gastric lymphomas.
Materials And Methods:
Immunostaining for the p27 protein was performed in 16 cases of low grade mucosa-associated lymphoid tissue (MALT) lymphomas and 16 cases of high grade B-cell lymphomas of the stomach.
Results:
All low grade MALT lymphomas were positive, however all high grade lymphomas were negative forp27 protein. Most of the monocytoid cells in the low grade lymphoma were unstained.
Conclusion:
Loss of p27 protein expression is well correlated with histologic grade and appears to be associated with the high grade transformation seen in primary gastric lymphomas.
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