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Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers

J S Kim, J S Bae, K H Kim

    Cancer Research and Treatment
    |December 19, 2015
    PubMed
    Abstract

    Insights

    Reduced PTEN protein expression and increased HER-2 protein expression are linked to thyroid cancer development. This study analyzed PTEN and HER-2 in thyroid tumors, finding significant correlations with cancer progression.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • The tumor suppressor gene PTEN (Phosphatase and Tensin homolog) is frequently altered in human cancers.
    • PTEN alterations are rare in sporadic thyroid cancers, necessitating further investigation into its role.
    • Understanding PTEN and HER-2/neu expression is crucial for thyroid cancer pathogenesis.

    Purpose of the Study:

    • To investigate PTEN protein expression in thyroid cancer.
    • To examine the relationship between PTEN expression and clinical factors in thyroid cancer.
    • To analyze the correlation of PTEN expression with HER-2/neu and p53 in thyroid cancer.

    Main Methods:

    • Immunohistochemical staining was performed on 62 thyroid cancer and 24 benign thyroid tumor specimens.
    • Monoclonal antibodies against PTEN, HER-2/neu, and p53 were used.
    • Statistical analysis was conducted to evaluate the results.

    Main Results:

    • PTEN under-expression was significantly more frequent in thyroid cancers (29%) compared to benign tumors (4.2%).
    • PTEN expression reduction was not significantly related to tumor size, age, lymph node metastasis, or p53 status.
    • A significant relationship was found between PTEN under-expression and HER-2 over-expression (p=0.001) in thyroid cancers. HER-2 over-expression was noted in 83.8% of thyroid cancers versus 16.7% of benign tumors.

    Conclusions:

    • Under-expression of PTEN protein and over-expression of HER-2 protein may contribute to thyroid cancer development.
    • These molecular alterations suggest potential roles in thyroid carcinogenesis.
    • Further research into PTEN and HER-2 pathways could inform therapeutic strategies for thyroid cancer.
    Keywords:
    Her-2/neu geneImmunohistochemical stainingPTEN geneThyroid neoplasmp53 gene

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