Related Experiment Video
Updated: Mar 28, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
l-myc Polymorphism in Gastric Cancer, Lung Cancer, and Hepatocellular Carcinoma
Purpose:
This study was performed to see if a particular polymorphism in the l-myc, a nuclear oncogene at the 1p32 locus, might be associated with greater risk of gastric cancer, lung cancer and hepatocellular carcinomas (HCC) in Korean patients.
Materials And Methods:
Genomic DNA, derived from patients diagnosed with gastric cancer (n=57), lung cancer (n=39), HCC (n=35) and healthy individuals (n= 176), was examined. The l-myc polymorphism under study was visualized by PCR followed by EcoRI digestion.
Results:
There was no significant difference in the distribution of the l-myc polymorphism genotypes and allele frequencies between the cancer patients and the controls.
Conclusion:
The l-myc polymorphism does not appear to be indicative of elevated risk of cancers of the stomach, lung and HCC.
Related Concept Videos
Induced Pluripotent Stem Cells
Somatic...
Abnormal Proliferation
lncRNA - Long Non-coding RNAs
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Non-LTR Retrotransposons

