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Related Experiment Video

Updated: Mar 28, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Engineering of Lanthanide-Doped Upconversion Nanoparticles for Optical Encoding.

Kai Huang1, Niagara Muhammad Idris1, Yong Zhang1

  • 1Department of Biomedical Engineering, National University of Singapore, 117575, Singapore.

Small (Weinheim an Der Bergstrasse, Germany)
|December 19, 2015
PubMed
Summary

Lanthanide-doped upconversion nanoparticles (UCNPs) offer advanced optical encoding for multiplexed bio-imaging. Researchers reviewed UCNP properties and fabrication strategies for enhanced optical encoding applications.

Keywords:
core-shell structureslanthanidesmicrobeadsnanoparticlesoptical encoding

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Optics

Background:

  • Lanthanide-doped upconversion nanoparticles (UCNPs) exhibit unique luminescence properties, including a large anti-Stokes shift, sharp spectral bands, and excellent stability.
  • Their ability to emit UV/visible light under near-infrared (NIR) excitation, coupled with NIR's deep tissue penetration and low autofluorescence, makes them superior to conventional fluorophores in bioapplications.

Purpose of the Study:

  • To review the mechanisms and strategies for developing lanthanide-doped upconversion nanoparticles (UCNPs) for advanced optical encoding.
  • To explore the potential of UCNPs in multiplexed detection and imaging applications.

Main Methods:

  • Review of UCNP properties such as emission/excitation wavelengths, ratiometric intensity, and luminescence lifetime.
  • Analysis of engineering strategies including homogeneous ion doping, heterogeneous structure fabrication, and microbead encapsulation for UCNP optical encoding.
  • Discussion of challenges and potential solutions in UCNP optical encoding.

Main Results:

  • UCNPs possess tunable optical properties (emission, excitation, lifetime, size) enabling precise microstructure control.
  • Various strategies have been developed to engineer UCNP optical properties for effective optical encoding.
  • Significant progress has been made in overcoming challenges related to UCNP optical encoding.

Conclusions:

  • UCNPs are highly promising for optical encoding due to their tunable and stable luminescence properties.
  • Further development in UCNP fabrication and encoding strategies will expand their utility in multiplexed detection and bio-imaging.
  • Addressing current challenges will unlock the full potential of UCNPs in advanced optical applications.