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Updated: Mar 28, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local
Sahar G Eid1, Niamh E Mangan2, Paul J Hertzog2
1Deakin University , Greelong, Victoria, Australia ; CSIRO Australian Animal Health Laboratory , Newcomb, Victoria, Australia.
Abstract:
The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides' clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
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